A step forward to treat kidney disease using mice
Researchers at EARA member the University of Padua, Italy, have found a potential target for the early treatment of kidney inflammation caused by lupus.
Lupus occurs when the body’s immune system attacks its own tissues and organs. One of the most severe forms of this condition is lupus nephritis, a type of kidney disease that could lead to kidney failure.
To understand the role of Pentraxin3 (PTX3) – a molecule known to be unbalanced in human lupus - the team observed that mice immunised with PTX3 developed a protective immunity, preventing them from developing lupus nephritis.
“Animal research allows us to make crucial advances when dealing with rarer conditions in which targeted treatments - instead of lifelong dependence on drugs - are paramount for a better outcome in terms of both survival and the quality of life of our patients,” said Mariele Gatto of University of Padua.